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The effects of norepinephrine (NE) and peripheral insulin on food intake in rats were investigated. Blood was collected from intact, adrenalectomized (ADX), and ADX+epinephrine (EPI) rats before and after administration of 0.5 mumol (or vehicle) given intraperitoneally (IP) immediately prior to daytime meal presentation. The results demonstrate that 1) EPI and NE are pharmacologically distinct from one another: EPI decreased food intake in all groups, whereas NE decreased food intake only in intact, but not ADX, rats; 2) EPI and NE have similar effects on food intake of ADX rats: EPI decreases food intake in both intact and ADX rats, whereas NE does not; and 3) NE does not mimic the effect of EPI on food intake of intact rats. The results are discussed with respect to the role of pituitary hormones, especially growth hormone, in daytime feeding behavior.1. Field of the Invention
The invention relates generally to the field of administration of therapeutic compositions to the eye. More particularly, the invention relates to controlled release drug delivery devices and their method of manufacture, as well as related systems and kits.
2. Background of the Invention
Various drug delivery methods exist for delivery of medication, for example, to the eye. Some delivery methods include eye drops, ointments, subconjunctival injections, subconjunctival implants, intravitreal implants, and the like. A drug delivery device for controlled release of medication, including a device for intraocular sustained release, may be used to administer drugs to eyes. These devices are especially useful in the treatment of diseases such as macular degener 0b46394aab
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